A LARGE RANGE OF SYNERGISTIC QUALITIES

PERFECT ANTIGENS
ASSOCIATED WITH EXOSOMES PROPERTIES

The ciloa technology is the only one to produce all types of fully native membrane and cytosolic proteins on exosomes. Ciloa membrane proteins on exosomes are perfect because they are produced using only natural eukaryotic cellular mechanisms, without the use of mutagenesis, detergents or viral capsids.

NATIVE MEMBRANE PROTEIN COMPLEXES
  • The membrane protein exhibits all its natural post-translational modifications.
  • The membrane protein is naturally embedded in a natural phospholipid membrane.
  • Several proteins can be targeted in the same exosome, allowing sorting of membrane protein complexes.
SORTING OF ONLY SELECTED TARGETS
  • The chosen protein is selectively enriched.
  • Contamination by other proteins is much lower than with membrane protein extracts.
  • The membrane protein undergoes no artefactual manipulation.
HOMOGENEOUS, STABLE, HIGH IMMUNE RESPONSE
  • Exosomes are stable nano-vesicles.
  • The shape of exosomes better presents antigens.
  • Thanks to the powerful natural adjuvant properties of exosomes, the immune response is very high.

PERFECT ANTIGENS FOR PERFECT ANTIBODIES

POWERFULL ASSAYS

RECOMBINANT EXOSOMES
HIGH VALUE ANALYTICAL TECHNIQUES

Ciloa produces all types of complex membrane proteins, including GPCRs, on natural exosomes.

They can be used in a wide range of time-efficient and cost-saving assays for receptor-ligand studies such as SPR (Surface Plasmon Resonance) and ELISA.

Recombinant exosomes give an effective way to develop :

  • Diagnostic tests that require conformational epitopes of  membrane proteins.
  • Polyclonal or monoclonal antibodies specific to conformational epitopes.
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